[評讀高分期刊] 幹細胞的治療對人類疾病的應用

本文評讀以下 SCI 高分期刊論文

Stem cell-based therapy for human diseases. Sig Transduct Target Ther 7, 272 (2022). https://doi.org/10.1038/s41392-022-01134-4 ( Impact factor ~ 41 ,2023 )

期刊的影響因子、相關性與貢獻

期刊的影響因子：

《Signal Transduction and Targeted Therapy》是生物醫學領域內具備高影響因子（15以上）的知名期刊。鑑於該期刊的影響力，它所刊登的研究應具有突破性或對轉譯醫學及治療干預領域有重大影響。

文章與期刊標準的相關性：

本文符合該期刊影響因子所對應的標準。文章涵蓋了幹細胞療法的全面回顧，尤其是聚焦於人類多能幹細胞（hPSCs）和間質幹細胞（MSCs），並對其在各類疾病中的臨床應用進行了詳盡的討論。文章對臨床試驗的深度分析與期刊強調的靶向治療主題高度契合。

實質性貢獻：

本文對幹細胞療法的詳細剖析及未來研究方向的討論顯示其內容足以在此高影響因子期刊上發表。該文聚焦於將臨床前研究成果轉化為臨床應用，這對期刊讀者群體至關重要。

評估超越影響因子的潛在影響

A. 與當前辯論或領域空白的相關性

• 時效性與新興趨勢：幹細胞療法是一個快速發展的領域。本文既探討了當前MSC與hPSC療法的前景，也討論了其局限性，特別是在幹細胞醫療旅遊及未經監管的診所所帶來的挑戰背景下，文章的相關性極高。
• 文獻空白：本文強調了MSC組織來源的重要性，這是一個尚未深入研究的領域，可能解釋臨床結果中的差異。這一焦點為文獻提供了新的見解，填補了關鍵的研究空白。
• 跨學科吸引力：雖然本文主要關注再生醫學，但其討論MSC在腫瘤學、神經學及心臟病學中的應用，具有跨學科的相關性。

B. 對理論或實踐的貢獻

• 理論進展：關於MSC組織來源對治療結果影響的假設是一個重要的理論貢獻，可能會對未來優化幹細胞療法的研究產生影響。
• 實踐應用：本文對臨床試驗的探索提供了實際的見解，有助於改善試驗設計和治療應用，對臨床醫生和研究人員都有重要價值。

C. 方法學嚴謹性與新穎性

• 方法創新：本文引入了MSC組織來源的有趣概念，儘管這本身並不是方法學上的創新，但它提出了一種新的視角，可能引領更具針對性和更有效的療法。
• 可重複性與透明性：文章引用了多個臨床試驗，並對其結果、局限性及方法論進行了透明的討論，支持其研究的可重複性。

D. 引文潛力及未來研究

• 來自不同領域的引用：鑑於其跨學科性質，該文章有可能來自再生醫學、腫瘤學和神經學等多個領域的引用。
• 研究網絡效應：作者來自知名機構，這可能擴大該文章在學術網絡中的影響力。

引用指標與替代指標

A. 引用潛力

• 即時影響：文章討論了幹細胞研究的當前趨勢，隨著該領域的進一步發展，預計該文章會迅速產生影響。
• 長期影響：其對MSC組織來源這一未充分研究領域的關注，將賦予其長期的學術相關性，使其在未來的評論文章或綜合分析中成為常被引用的資料。

B. 替代指標（Altmetrics）

• 公眾參與：幹細胞療法對公眾具有極大的吸引力，尤其是在治療過去無法治癒的疾病方面。隨著該領域的發展，該文章可能在社交媒體和主流媒體中引發關注。

從研究的角度評估影響

A. 可重複性與透明性

• 數據共享與開放訪問：本文以開放訪問模式發表，這增加了其可見性和其他研究者引用的可能性。
• 預註冊與開放科學：雖然未明確提到，但文章引用的許多臨床試驗遵循嚴格的預註冊協議，增強了其可信度。

B. 涉及有爭議或未充分研究的領域

• 有爭議的話題：本文討論了未經證實的幹細胞療法，特別是在私人診所中的應用，這增加了其在指導該領域倫理實踐方面的重要性。
• 新興前沿：關於MSC組織來源的討論是開創性的，可能激發新的研究方向，使其在未來具有很大的影響力。

超越文章本身的影響

A. 作者影響力與研究網絡

• 作者聲望：本文的作者來自如斯坦福大學和基爾大學等知名研究機構，這可能增加該文章在學術圈的影響力。
• 合作網絡：該研究涉及多國機構的合作，表明該文章可能具有更廣泛的影響力。

B. 社會與政策影響

• 現實應用：該文聚焦於幹細胞療法的臨床試驗和實際應用，可能影響醫療指南和治療實踐，特別是在再生醫學領域。
• 長期社會相關性：隨著幹細胞療法的發展，該文對安全性、有效性及倫理問題的討論將在未來數年內保持相關性。

在背景下評估影響

• 領域特定引用規範：再生醫學通常具有較高的引用率，本文聚焦於臨床試驗和轉譯研究，應會遵循此趨勢。
• 期刊在該領域的作用：《Signal Transduction and Targeted Therapy》是生物醫學領域中的高影響力期刊，該文章在探討基礎科學和臨床應用方面與期刊的範疇高度契合。

結論：在影響因子與影響力間權衡

• 該文章符合期刊的影響因子標準，為幹細胞研究提供了有意義的貢獻，且在學術界和臨床實踐中具有高度的影響潛力。

1. Understanding the Journal’s Impact Factor

• Journal's Impact Factor: "Signal Transduction and Targeted Therapy" is a reputable journal in the biomedical field with a high impact factor (above 15). Given the journal's prominence, it expects research to be groundbreaking or significantly influential in the field of translational medicine and therapeutic interventions.
• Article's Relevance to Journal's Standards: The article meets the standards associated with the journal’s impact factor. It covers a comprehensive review of stem cell therapies, particularly focusing on human pluripotent and mesenchymal stem cells, and provides an extensive discussion of their clinical applications across a variety of diseases. The depth of analysis on clinical trials aligns well with the journal’s emphasis on targeted therapies.
• Substantial Contribution: The detailed breakdown of stem cell therapies and discussion of future research directions show that the article is substantial enough to warrant publication in this high-impact journal. Its focus on translating preclinical findings into clinical applications is crucial for the journal's readership.

2. Assessing Potential Influence Beyond Impact Factor

A. Relevance to Ongoing Debates or Gaps in the Field

• Timeliness and Emerging Trends: Stem cell-based therapies are a rapidly evolving field. The article addresses both the promise and limitations of current MSC and hPSC therapies, making it highly relevant to ongoing debates about their efficacy and safety, particularly in light of the challenges posed by stem cell tourism and unregulated clinics.
• Gap in the Literature: The review highlights the importance of considering the tissue origin of MSCs, which is an underexplored area that could potentially explain discrepancies in clinical outcomes. This focus on the origin of stem cells adds novel insights and fills a crucial gap in the literature.
• Interdisciplinary Appeal: While primarily focused on regenerative medicine, the article has interdisciplinary relevance, potentially impacting fields like oncology, neurology, and cardiology through its discussion of MSC applications in treating various diseases.

B. Contribution to Theory or Practice

• Theoretical Advancement: The hypothesis regarding the tissue origin of MSCs affecting therapeutic outcomes is a significant theoretical contribution. It could influence future research on the optimization of stem cell therapies.
• Practical Implications: The article’s exploration of clinical trials provides practical insights that could help improve trial designs and therapeutic applications, making it valuable for clinicians and researchers alike.

C. Methodological Rigor and Novelty

• Innovation in Methods: The review introduces an interesting concept of MSC tissue origin, and though it is not a methodological innovation per se, it proposes a new perspective that could lead to more targeted and effective therapies.
• Reproducibility and Transparency: The article references multiple clinical trials and provides a transparent discussion of their outcomes, limitations, and methodologies, which supports reproducibility.

D. Potential for Citations and Future Research

• Citations from Different Fields: Given its interdisciplinary nature, the article is likely to attract citations from various fields, including regenerative medicine, oncology, and neurology.
• Network Effects in Research: The authors are associated with prestigious institutions, which could amplify the article's reach and influence within academic networks.

3. Citation Metrics and Alternative Metrics

A. Citation Potential

• Immediate Impact: The article addresses current trends in stem cell research and is likely to have an immediate impact, especially as the field continues to grow.
• Long-term Impact: Its focus on underexplored areas, such as MSC tissue origin, could give it long-term relevance and make it a frequently cited piece in future reviews or meta-analyses.

B. Alternative Metrics (Altmetrics)

• Public Engagement: Stem cell therapies are of great interest to the general public, particularly regarding their potential for treating previously incurable diseases. The article could garner attention on social media and in mainstream media, especially as the field progresses.

4. Assessing Influence through the Lens of Research Quality

A. Replicability and Transparency

• Data Sharing and Open Access: The article is published under an open-access license, which increases its visibility and potential for citation by other researchers.
• Pre-registration and Open Science: While not explicitly discussed, the article references clinical trials, many of which follow rigorous pre-registration protocols, enhancing its credibility.

B. Addressing Controversial or Underexplored Areas

• Controversial Topics: The article addresses the controversial use of unproven stem cell therapies, particularly in private clinics, which adds to its importance in guiding ethical practices in the field.
• New Frontiers: The discussion on MSC tissue origin is pioneering and could stimulate new research directions, making it highly influential in the future.

5. Influence Beyond the Article Itself

A. Author Influence and Research Network

• Author Prestige: The article’s authors are affiliated with well-known research institutions like Stanford University and Keele University, which could increase the article’s influence within academic circles.
• Collaborative Networks: The collaborative nature of the research, involving institutions across different countries, suggests the article may have a broader reach.

B. Societal and Policy Impact

• Real-World Applications: The article’s focus on clinical trials and practical applications of stem cell therapies positions it to influence healthcare guidelines and therapeutic practices, particularly in regenerative medicine.
• Long-term Societal Relevance: As stem cell therapies continue to develop, the article’s discussions on safety, efficacy, and ethical concerns will remain relevant for years to come.

6. Assessing Impact with Context

• Field-Specific Citation Norms: Regenerative medicine tends to have high citation rates, and this article is positioned to follow this trend, given its focus on clinical trials and translational research.
• Journal’s Role in the Field: "Signal Transduction and Targeted Therapy" is a high-impact journal in the biomedical field, and this article fits well within its scope by addressing both basic science and clinical applications.

Conclusion: Weighing Impact Factor and Influence

• Recommendation: The article meets the standards of the journal’s impact factor, providing a meaningful contribution to stem cell research with potential for high influence in both academia and clinical practice. No major revisions are necessary, though expanding on the discussion of clinical trial limitations could further strengthen its impact.

此為 [ 醫淬思AI Lab ] 與授課學員、醫療社群進行實驗的AI文章 

請善用文獻檢索與原文閱讀進行內容驗證與使用